Product Name |
FTY720-d4 Hydrochloride
|
Product Code |
DA-F035-ac
|
Chemical name |
FTY720-d4 Hydrochloride
|
Synonyms |
2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol-d4 Hydrochloride; Fingolimod-d4 Hydrochloride;
|
Impurity |
NA
|
CAS Number |
1346604-90-7
|
Alternate CAS # |
NA
|
Molecular form |
C19H30D4ClNO2
|
Appearance |
White Solid
|
Melting Point |
NA
|
Mol. Weight |
347.96
|
Storage |
2-8°C Refrigerator
|
Solubility |
NA
|
Stability |
NA
|
Category |
aromatics,enzyme inhibitors,metabolites,impurities,pharmaceutical standards,intermediates,fine chemicals,stable isotopes
|
Boiling Point |
NA
|
Applications |
A labelled derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
|
Dangerous Goods Info |
NA
|
References |
NA
|
Extra Notes |
NA
|
Documents (MSDS) |
No Data Available
|
Keywords |
NA |