Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-aprepitant
| Product Name |
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-aprepitant
|
| Product Code |
DA-A280-11
|
| Chemical name |
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-aprepitant
|
| Synonyms |
(2S,3R)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine;aprepitant M2 Metabolite (1R, 2S, 3R)-Isomer;
|
| Impurity |
NA
|
| CAS Number |
1185503-48-3
|
| Alternate CAS # |
NA
|
| Molecular form |
C20H18F7NO2
|
| Appearance |
NA
|
| Melting Point |
NA
|
| Mol. Weight |
437.36
|
| Storage |
2-8°C Refrigerator
|
| Solubility |
NA
|
| Stability |
NA
|
| Category |
impurities,metabolites,pharmaceutical standards,intermediates,fine chemicals
|
| Boiling Point |
NA
|
| Applications |
Des-1,2,4-triazol-3-one-5-methyl (2S,3R,1'R)-Aprepitant is an impurity of Aprepitant ; a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
|
| Dangerous Goods Info |
NA
|
| References |
NA
|
| Extra Notes |
NA
|
| Documents (MSDS) |
No Data Available
|
| Keywords |
NA |
