| Product Name | Methylnaltrexone Bromide |
| Product Code | DA-N014-g |
| Chemical name | Methylnaltrexone Bromide |
| Synonyms | (17RS)-17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium Bromide; N-Methyl Naltrexone Bromide; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium Bromide; |
| Impurity | NA |
| CAS Number | 73232-52-7 |
| Alternate CAS # | NA |
| Molecular form | C21H26BrNO4 |
| Appearance | White to Pale Brown Solid |
| Melting Point | NA |
| Mol. Weight | 436.35 |
| Storage | 2-8°C Hygroscopic, Refrigerator, Under Inert Atmosphere |
| Solubility | NA |
| Stability | NA |
| Category | impurities,metabolites,pharmaceutical standards,intermediates,Fine Chemicals |
| Boiling Point | NA |
| Applications | A metabolite of Naltrexone. Methylnaltrexone, a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance. |
| Dangerous Goods Info | NA |
| References | NA |
| Extra Notes | NA |
| Documents (MSDS) | No Data Available |
| Keywords | NA |
