Abacavir Sulfate - Impurity D (Dihydrochloride Salt)
| Product Name |
Abacavir Sulfate - Impurity D (Dihydrochloride Salt)
|
| Product Code |
DA-A003-06
|
| Chemical name |
trans-Abacavir Dihydrochloride
|
| Synonyms |
(1R,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol Diydrochloride; ((1R,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol Dihydrochloride;
|
| Impurity |
NA
|
| CAS Number |
NA
|
| Alternate CAS # |
NA
|
| Molecular form |
C14H20Cl2N6O
|
| Appearance |
Pale Yellow to Pale Orange Solid
|
| Melting Point |
NA
|
| Mol. Weight |
359.25
|
| Storage |
2-8°C Refrigerator
|
| Solubility |
NA
|
| Stability |
NA
|
| Category |
intermediates,pharmaceutical standards,enzyme inhibitors,Fine Chemicals,bases and related reagents,nucleotides
|
| Boiling Point |
NA
|
| Applications |
Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
|
| Dangerous Goods Info |
NA
|
| References |
NA
|
| Extra Notes |
NA
|
| Documents (MSDS) |
No Data Available
|
| Keywords |
NA |
