| Product Name | Epothilone D |
| Product Code | DA-E093-05 |
| Chemical name | Epothilone D (synthetic) |
| Synonyms | (4S,7R,8S,9S,16S,Z)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)oxacyclohexadec-13-ene-2,6-dione; |
| Impurity | NA |
| CAS Number | 189453-10-9 |
| Alternate CAS # | NA |
| Molecular form | C27H41NO5S |
| Appearance | White Solid |
| Melting Point | NA |
| Mol. Weight | 491.69 |
| Storage | 2-8°C Refrigerator |
| Solubility | NA |
| Stability | NA |
| Category | enzyme activators,enzyme inhibitors,pharmaceutical standards,impurities,metabolites,fine chemicals |
| Boiling Point | NA |
| Applications | Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical testing of in patients with advanced solid tumours. Epothilone D is a cytotoxic macrolide that stabilises malignant cells' microtubules and arrests mitosis, a characteristic it shares with other epothilones. They bind to the same hepatic sites as does paclitaxel (Taxol) in a 1:1 stoichiometric ratio of a, b-tubulin heterodimers. |
| Dangerous Goods Info | NA |
| References | NA |
| Extra Notes | NA |
| Documents (MSDS) | No Data Available |
| Keywords | NA |
